Cytokinesis: Sid signals septation
نویسندگان
چکیده
منابع مشابه
Cytokinesis: Sid signals septation
Like DNA replication or chromosome segregation, cytokinesis is a once-and-only-once event in the life of a cell. What controls where, when and how a cell divides? The fission yeast Schizosaccharomyces pombe has recently become a focus for genetic studies of eukaryotic cytokinesis, and this work has revealed, among other things, a novel signal transduction pathway controlling septation [1–3]. Wh...
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When the essential and distinctive cell walls of either pathogenic or nonpathogenic fungi break, cytoplasmic membranes rupture and fungi die. This fungicidal activity was discovered previously on nonproliferating Saccharomyces cerevisiae cells treated briefly with the oxidative tool and anticancer drug family of bleomycins. The present studies investigated effects of bleomycin on growing fungal...
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In fungi, as with all walled organisms, cytokinesis followed by septation marks the end of the cell cycle and is essential for cell division and viability. For yeasts, the septal cross-wall comprises a ring and primary septal plate composed of chitin, and a secondary septum thickened with β(1,3)-glucan. In the human pathogen Candida albicans, chitin synthase enzyme Chs1 builds the primary septu...
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In Schizosaccharomyces pombe, late mitotic events are coordinated with cytokinesis by the septation initiation network (SIN), an essential spindle pole body (SPB)-associated kinase cascade, which controls the formation, maintenance, and constriction of the cytokinetic ring. It is not fully understood how SIN initiation is temporally regulated, but it depends on the activation of the GTPase Spg1...
متن کاملThe septation initiation network controls the assembly of nodes containing Cdr2p for cytokinesis in fission yeast.
In the fission yeast Schizosaccharomyces pombe, cortical protein structures called interphase nodes help to prepare the cell for cytokinesis by positioning precursors of the cytokinetic contractile ring, and the septation initiation network (SIN) regulates the onset of cytokinesis and septum formation. Previous work has noted that one type of interphase node disappears during mitosis providing ...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2000
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(00)00613-8